Central Nervous System

This group in Kalceks portfolio contains hypnotics, sedatives and psychoanaleptics/psychostimulants for usage in hospitals including premedication needs and intensive care units.

Products

Title
Alfentanil injection
Strength 0.5 mg/ml
Volume 1 ml, 2 ml, 10 ml
ATC code N01AH02

ANESTHETICS, GENERAL

Apomorphine hydrochloride hemihydrate injection*
Strength 5 mg/ml
Volume 10 ml
ATC code N04BC07

Anti-parkinson drugs, dopaminergic agents

*under development

Buprenorphine transdermal patches*
Strength 5 μg/h, 10 μg/h, 20 μg/h
ATC code N02AE01

Analgesics, Opioids

Dexmedetomidine injection
Strength 100 µg/ml
Volume 2 ml, 4 ml, 10 ml
ATC code N05CM18

HYPNOTICS AND SEDATIVES

This medicine provide sedation (a state of calm, drowsiness or sleep) for adult patients in hospital intensive care settings.

Droperidol injection
Strength 1.25 mg/ml, 2.5 mg/ml
Volume 1 ml
ATC code N05AD08

PSYCHOLEPTICS, ANTIPSYCHOTICS

The product is indicated for:
- Prevention and treatment of post-operative nausea and vomiting in adults and, as second line, in children (2 to 11 years) and adolescents (12 to 18 years).
- Prevention of nausea and vomiting induced by morphine derivatives during post-operative patient controlled analgesia (PCA) in adults.

Esketamine injection
Strength 5 mg/ml, 25 mg/ml
Volume 2 ml, 5 ml, 10 ml
ATC code N01AX14

ANESTHETICS, GENERAL

This medicine belongs to one of a group of medicines called anaesthetic agents, which are used to put you to sleep during an operation.
This medicine can be given:
- alone or in combination with other anaesthetic agents;
- as a pain relief/anaesthesia in emergency situations;
- can be used for supplementing regional or local anaesthesia.

Fentanyl injection
Strength 0.05 mg/ml
Volume 2 ml, 10 ml
ATC code N01AH01

ANESTHETICS, GENERAL

This medicine is used:
- as a narcotic analgesic supplement in general or regional anaesthesia;
- in combination with a neuroleptic (e.g. droperidol) in the technique of neuroleptanalgesia;
- for the induction of anaesthesia, and as an adjuvant in the maintenance of general and regional anaesthesia;
- as an anaesthetic agent with oxygen in high-risk patients undergoing surgery.

Fentanyl nasal spray*
Strength 50 µg/dose, 200 µg/dose
Volume 2.9 ml
ATC code N02AB03

ANALGESIC, OPIOID

*under development

Fentanyl sublingual tablets*
Strength 100 μg, 200 μg, 300 μg, 400 μg, 600 μg, 800 μg
Volume -
ATC code N02AB03

ANALGESICS, OPIOIDS

*under development

Fentanyl transdermal patches*
Strength 12.5 μg/h, 25 μg/h, 50 μg/h, 75 μg/h, 100 μg/h
ATC code N02AB03

Analgesics, Opioids

Hydromorphone hydrochloride injection
Strength 2 mg/ml, 10 mg/ml, 20 mg/ml, 50 mg/ml
Volume 1 ml
ATC code N02AA03

ANALGESIC, OPIOID

This medicine is used for the treatment of severe pain.

Metamizole sodium monohydrate injection
Strength 500 mg/ml
Volume 2 ml, 5 ml
ATC code N02BB02

ANALGESICS, OTHER ANALGESICS AND ANTIPYRETICS

This medicine is used for treatment of severe acute or chronic pain. Fever not responding to other treatment.

Midazolam injection
Strength 1 mg/ml, 5 mg/ml
Volume 1 ml, 3 ml, 5 ml, 10 ml
ATC code N05CD08

HYPNOTICS AND SEDATIVES

This medicine is a short-acting hypnotic with the following indications for use:

Adults
• CONSCIOUS SEDATION with or without local anaesthesia before or during diagnostic or therapeutic procedures
• ANAESTHESIA
- Premedication before the induction of anaesthesia
- Induction of anaesthesia
- As a sedative component in maintenance of anaesthesia
• SEDATION IN THE INTENSIVE CARE UNIT

Children
• CONSCIOUS SEDATION with or without local anaesthesia before or during diagnostic or therapeutic procedures
• ANAESTHESIA
- Premedication before the induction of anaesthesia
• SEDATION IN THE INTENSIVE CARE UNIT

Morphine hydrochloride injection
Strength 10 mg/ml, 20 mg/ml
Volume 1 ml, 5 ml, 10 ml
ATC code N02AA01

ANALGESIC, OPIOID

This medicine is used for treatment of severe pain conditions which can be adequately managed only with opioid analgesics. Myocardial infarction, acute pulmonary oedema.

Morphine prolonged release tablets*
Strength 10 mg, 30 mg, 60 mg, 100 mg
ATC code N02AA01

Analgesics, Opioids

Morphine sulfate injection (w/o preservatives)
Strength 2 mg/ml, 5 mg/ml, 10 mg/ml, 15 mg/ml, 30 mg/ml
Volume 1 ml
ATC code N02AA01

ANALGESIC, OPIOID

This medicine is used for the relief of severe pain. It is also used to treat breathlessness caused by fluid in the lungs and as a pre-medication before operations.

Nefopam hydrochloride  injection*
Strength 10 mg/ml
Volume 2 ml
ATC code N02BG06

ANALGESICS, OTHER

* under development

Neostigmine metilsulfate injection
Strength 0.5 mg/ml
Volume 1 ml
ATC code N07AA01

OTHER NERVOUS SYSTEM DRUGS, PARASYMPATHOMIMETICS

This medicine is indicated for:
- myasthenia gravis.
- reversal of the neuromuscular blockade produced by non-depolarising neuromuscular blockers.
- paralytic ileus.
- management of postoperative urinary retention.

Ondansetron injection*
Strength 2 mg/ml
Volume 2 ml, 4 ml
ATC code A04AA01

Antiemetics and Antinauseants

*under development

Oxycodone hydrochloride injection/infusions
Strength 10 mg/ml, 50 mg/ml
Volume 1 ml, 2 ml
ATC code N02AA05

ANALGESIC, OPIOID

This medicine is used for:
- treatment of moderate to severe pain in patients with cancer and postoperative pain;
- treatment of severe pain requiring the use of a strong opioid.

Oxycodone prolonged release tablets*
Strength 5 mg, 10 mg, 20 mg, 40 mg, 80 mg
ATC code N02AA05

Analgesics, Opioids

Piracetam injection
Strength 200 mg/ml
Volume 5 ml, 10 ml
ATC code N06BX03

PSYCHOANALEPTICS, PSYCHOSTIMULANTS, AGENTS USED FOR ADHD AND NOOTROPICS

This medicine is used for treatment of dizziness of central origin and its related symptoms.
Treatment of myoclonus caused by cerebral cortex damage in combination with other anti-myoclonic medicines.

Remifentanil powder for concentrate for solution for injection/infusion*
Volume 1 mg, 2 mg, 5 mg
ATC code N01AH06

ANESTHETICS, GENERAL

*under development

Rivastigmine transdermal patches*
Strength 4.6 μg/24h, 9.5 μg/24h, 13.3 μg/24h
ATC code N06DA03

Anti-dementia drug

*under development

Ropivacaine hydrochloride  injection*
Strength 2 mg/ml, 5 mg/ml, 7.5 mg/ml, 10 mg/ml
Volume 10 ml, 20 ml, 100 ml, 200 ml
ATC code N01BB09

ANESTHETICS, LOCAL

* under development

Sodium oxybate oral solution
Strength 500 mg/ml
Volume 180 ml
ATC code N07XX04

Other nervous system drugs

Treatment of narcolepsy with cataplexy in adult patients.

Sufentanil injection*
Strength 0.005 mg/ml, 0.05 mg/ml
Volume 2 ml, 5 ml, 10 ml
ATC code N01AH03

ANESTHETICS, GENERAL

*under development

Tramadol hydrochloride injection
Strength 50 mg/ml
Volume 1 ml, 2 ml
ATC code N02AX02

ANALGESIC, OPIOID

This medicine is used for treatment of moderate to severe pain.

Trimeperidine hydrochloride injection
Strength 20 mg/ml
Volume 1 ml
ATC code N02AX

ANALGESIC, OPIOID

This medicine is used to relieve severe pain in the case of injuries, fractures of bones, burns, miocardial infarction, acute pancreatitis, renal, biliary and intestinal colic, in the case of malignant tumour, as well as after surgery.
To relieve labour pain and to accelerate labour in the case of cervical dysfunction, when epidural anaesthesia is impossible and childbirth is predictable not earlier than after two hours.
For premedication before surgery.